NeuroICU at St. George’s University Hospitals NHS Foundation Trust is research active.
Current Randomised Controlled Trials
The Neuro-ICU at St. George’s contributes to the following trials. Some of these trials have started recruitment and others are currently being set-up.
DISCUS
Cervical traumatic spinal cord injury https://fundingawards.nihr.ac.uk/award/NIHR130048.
Novel neurosurgical treatment and multi-modality monitoring from injury site
Lead site: St George’s, University of London
SCIL
Subarachnoid haemorrhage https://www.clinicaltrials.gov/ct2/show/NCT03249207?term=scil&cond=Subarachnoid+Hemorrhage&draw=2&rank=1.
Novel drug treatment
Lead site: University of Manchester
ISCoPE
Traumatic spinal cord injury https://www.clinicaltrials.gov/ct2/show/NCT02721615?term=ISCOPE&cond=Spinal+Cord+Injuries&draw=2&rank=1
Multi-modality monitoring from injury site
Lead site: St George’s, University of London
MAST
Traumatic brain injury https://www.clinicaltrials.gov/ct2/show/NCT04573803?term=mast&cond=Brain+Injuries&draw=2&rank=1
Drug treatment for seizures
Lead site: Cambridge
CARE
Cavernous haemangioma https://www.clinicaltrials.gov/ct2/show/NCT04181086?term=CARE&cond=Cavernous+Hemangioma&draw=2&rank=1
To determine best treatment
Lead site: Edinburgh
POLYFIX (Fusion 4 DSM)
Degenerative cervical myelopathy https://cctu.org.uk/portfolio/surgical-peri-operative-care/trials-in-setup/polyfix-dcm
Fixation after multi-level cervical laminectomy
Lead site: Cambridge University Hospitals NHS Foundation Trust
BONANZA
Traumatic brain Injury https://www.anzics.com.au/current-active-endorsed-research/bonanza/
Brain tissue oxygen monitoring from injured brain
Lead site: Monash University, Melbourne
SOS
Traumatic brain Injury https://fundingawards.nihr.ac.uk/award/17/120/01
Mannitol vs hypertonic saline for raised intracranial pressure
Lead site: University Hospitals Birmingham NHS Foundation Trust
SIGNET
Statins for improving organ outcome in transplantation. https://fundingawards.nihr.ac.uk/award/NIHR131124
To investigate whether giving deceased organ donors a single dose of the drug Simvastatin, very inexpensive and safe, is beneficial for transplant
recipients.
Lead site: University of Newcastle
Completed Randomised Controlled Trials
The Neuro-ICU at St. George’s has contributed patients to the following trials.
RESCUEicp: Traumatic brain Injury https://www.nejm.org/doi/full/10.1056/nejmoa1605215
Role of decompressive craniectomy
Lead site: Cambridge
RESCUEicp ASDH: Acute subdural haematoma http://www.rescueasdh.org/
Role of decompressive craniectomy
Lead site: Cambridge
Dex-CSDH: Chronic Subdural Haematoma https://www.nejm.org/doi/full/10.1056/NEJMoa2020473
Role of dexamethasone
Lead site: Cambridge
STICH and STICH2: Lobar spontaneous Intracerebral Haematoma https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)60986-1/fulltext https://pubmed.ncbi.nlm.nih.gov/15680453/
Surgical evacuation vs. best medical care
Lead site: Newcastle
STITCH: Traumatic Intracerebral Haematoma https://pubmed.ncbi.nlm.nih.gov/25738794/
Surgical evacuation vs conservative management
Lead site: Newcastle
STASH: Subarachnoid haemorrhage https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70084-5/fulltext
Simvastatin for subarachnoid haemorrhage
Lead site: Cambridge
Research Team
NeuroICU and Neurosurgery at SGH collaborate closely within the field of research
- Dr Marios Papadopoulos – Professor of Neurosurgery
- Dr Argyro Zoumprouli – Consultant & Honorary Lecturer in Neuroanaesthesia & NeuroICU
- Dr Samira Saadoun – Senior Lecturer in Neuroscience
- Dr Andrew Hitchings – Reader in Clinical pharmacology & Honorary Consultant in NeuroICU
- Dr Ximena Watson – Consultant in NeuroICU
- Siobhan Kearney – NeuroICU research nurse
- Beatrice Quercetti – NeuroICU research nurse
- Vincent Ventura – NeuroICU research nurse
Neuro Intensive Care Unit 